Article
A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.
Cancer - 15 Jun 2010
Wei Sheng, Liu Zhensheng, Zhao Hui, Niu Jiangong, Wang Li-E, El-Naggar Adel K, Sturgis Erich M, Wei Qingyi
Abstract excerpt
BACKGROUND: The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to...
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