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Article

BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin.

Cancer science - 1 May 2010

Shim Hyun Jeong, Yun Joo Young, Hwang Jun Eul, Bae Woo Kyun, Cho Sang Hee, Lee Ji Hee, Kim Hee Nam, Shin Min Ho, Kweon Sun Seog, Lee Jae Hyuk, Kim Hyeoung Joon, Chung Ik Joo

Abstract excerpt

This study evaluated the influence of genetic polymorphism influencing drug metabolism on survival in taxane- and cisplatin-treated advanced gastric cancer (AGC). Peripheral blood samples from 207 AGC patients treated with first-line chemotherapy of taxane and cisplatin were used. We investigated polymorphisms that influenced the metabolism of taxane (ATP-binding cassette transporter B1 (ABCB1)), cisplatin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20331623
DOI: 10.1111/j.1349-7006.2010.01514.x
PMCID: PMC11158840

Genes

XRCC1
BRCA1
ABCB1
ERCC1
GSTM1
GSTP1
GSTT1
MTHFR
TYMS
XRCC3
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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