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Article

Statin users without an APOE-epsilon4 allele have increased insulin resistance.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

VanFossen Brian T, Watson G Stennis, Baker Laura D, Rhoads Kristoffer W, Cholerton Brenna A, Reger Mark A, Plymate Stephen R, Schellenberg Gerald, Craft Suzanne

Abstract excerpt

The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE epsilon4- (i.e., not having an epsilon4 allele) statin users had higher HOMA-IR values compared with epsilon4+/statin users (p=0.0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+...

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Source

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Identifiers

PMID: 20308781
DOI: 10.3233/JAD-2010-1319
PMCID: PMC2945621

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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