Article
Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites.
The Journal of steroid biochemistry and molecular biology - 1 Jul 2010
Hibler E A, Jurutka P W, Egan J B, Hu C, LeRoy E C, Martinez M E, Thompson P A, Jacobs E T
Abstract excerpt
The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D receptor (VDR). VDR forms a heterodimer with the retinoid X receptors (RXRs) that when bound to ligand influences the transcriptional control of genes that regulate circulating levels of vitamin D metabolites. Whether genetic variation in VDR or RXRA affects circulating levels of 1,25(OH)2D or 25(OH)D has not been established. We used a...
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