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Article

Epigenetic silencing of CYP24 in the tumor microenvironment.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2010

Johnson Candace S, Chung Ivy, Trump Donald L

Abstract excerpt

Calcitriol (1,25 dihydroxycholecalciferol) has significant anti-tumor activity in vitro and in vivo in a number of tumor model systems. We developed a system for isolation of fresh endothelial cells from tumors and Matrigel environments which demonstrate that CYP24, the catabolic enzyme involved in vitamin D signaling, is epigenetically silenced selectively in tumor-derived endothelial cells (TDEC). TDEC maintain...

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Identifiers

PMID: 20304059
DOI: 10.1016/j.jsbmb.2010.03.046
PMCID: PMC2906617

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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