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Article

Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene

24 Feb 2009

Abstract excerpt

Plasma concentrations of biologically active vitamin D (1,25-(OH)(2)D) are tightly controlled via feedback regulation of renal 1alpha-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes. In pregnancy, this regulation is uncoupled, and 1,25-(OH)(2)D levels are significantly elevated, suggesting a role in pregnancy progression. Epigenetic regulation of CYP27B1 and CYP24A1 has previously...

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PMID: 19237542
DOI: 10.1074/jbc.m809542200

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