Differential vitamin D 24-hydroxylase/<i>CYP24A1</i>gene promoter methylation in endothelium from benign and malignant human prostate

Abstract excerpt

Epigenetic alterations occur in tumor-associated vessels in the tumor microenvironment. Methylation of the CYP24A1 gene promoter differs in endothelial cells isolated from tumors and non-tumor microenvironments in mice. The epigenetic makeup of endothelial cells of human tumor-associated vasculature is unknown due to difficulty of isolating endothelial cells populations from a heterogeneous tissue...

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