Article
Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.
The Biochemical journal - 1 Jun 1991
van Dijk W, Pos O, van der Stelt M E, Moshage H J, Yap S H, Dente L, Baumann P, Eap C B
Abstract excerpt
The relative occurrence of genetic variants of human alpha 1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and...
Topics
- Animals
- Burns
- Carcinoma, Hepatocellular
- Cells, Cultured
- Cytokines
- Gene Expression
- Genetic Variation
- Glycosylation
- Humans
- Inflammation
- Liver