Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A non-functioning vitamin D receptor predisposes to leukaemoid reactions in mice.

Hematological oncology - 1 Dec 2010

Erben Reinhold G, Zeitz Ute, Weber Karin, Stierstorfer Birgit, Wolf Georg, Schmahl Wolfgang, Balling Rudi, Quintanilla-Martinez Leticia

Abstract excerpt

The vitamin D hormone 1,25-dihydroxyvitamin D(3) [1,25(OH)(2) D(3) ], the biologically active form of vitamin D, is not only essential for mineral metabolism but may have important functions beyond calcium homoeostasis. By gene targeting, we have recently generated mice expressing a functionally inactive mutant vitamin D receptor (VDR). After a change in environmental conditions from specific pathogen free (SPF)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Cells

Share to Organ Size

Share to Receptors, Calcitriol

Share to Serum Amyloid A Protein

Share to Spleen

Share to Splenomegaly

Source

Identifiers

PMID: 20301229
DOI: 10.1002/hon.938

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A non-functioning vitamin D receptor predisposes to leukaemoid reactions in mice.PMID 20301229Read ↗

Vitamin D and Human Health: Lessons from Vitamin D Receptor Null MiceSemantic proximity Read ↗

A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without AlopeciaSemantic proximity Read ↗

Premature aging in vitamin D receptor mutant mice.Semantic proximity Read ↗

Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets.Semantic proximity Read ↗

Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis.Semantic proximity Read ↗

Vitamin D receptor is essential for normal keratinocyte stem cell functionSemantic proximity Read ↗

A novel inborn error in the ligand-binding domain of the vitamin D receptor causes hereditary vitamin D-resistant rickets.Semantic proximity Read ↗

Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness.Semantic proximity Read ↗

Physiopathology of dental rickets in vitamin D receptor-ablated mice.Semantic proximity Read ↗

Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth.Semantic proximity Read ↗

Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses.Semantic proximity Read ↗

Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.