Article
Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment.
Pharmacogenetics and genomics - 1 May 2010
Suonsyrjä Timo, Donner Kati, Hannila-Handelberg Tuula, Fodstad Heidi, Kontula Kimmo, Hiltunen Timo P
Abstract excerpt
Varying results have been reported on the association of beta-adrenergic receptor polymorphisms with blood pressure (BP) response to beta-blockers. We investigated the influence of ADRB1 Ser49Gly and Arg389Gly, and ADRB2 Gly16Arg and Glu27Gln polymorphisms on ambulatory BP response to bisoprolol and three other antihypertensive drug monotherapies in a placebo-controlled, double-blind, cross-over study with 233...
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