Novel HLA-DRB1 alleles revealed by sequencing based typing, DRB1*04053 and DRB1*1143.

doi:10.1034/j.1399-0039.2002.590420.x

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Article

Novel HLA-DRB1 alleles revealed by sequencing based typing, DRB104053 and DRB11143.

Tissue antigens - 1 Apr 2002

Greville W D, Chapman G, Hogbin J-P, Dunckley H

Abstract excerpt

We report the discovery of two HLA-DRB1 alleles by sequencing based typing (SBT). DRB1*04053 differs from previously reported DRB1 alleles by a single synonymous nucleotide substitution, resulting in a unique polymorphism at codon 93. DRB1*1143 differs from previously identified DRB1 alleles by a single non-synonymous nucleotide substitution, resulting in a polymorphism observed in other DRB1 and DRB3 alleles1.

Topics

Alleles
Base Sequence
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 12135441
DOI: 10.1034/j.1399-0039.2002.590420.x

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