Article
Increased interleukin-2 production in response to human type I collagen stimulation in patients with systemic sclerosis.
Arthritis and rheumatism - 1 May 1991
Hawrylko E, Spertus A, Mele C A, Oster N, Frieri M
Abstract excerpt
Peripheral blood mononuclear cells (PBMC) from patients with systemic sclerosis (SSc) produced increased amounts of interleukin-2 (IL-2), in a dose-dependent manner, in response to stimulation with human type I collagen, whereas PBMC from normal subjects did not. At a dose of 50 micrograms human type I collagen/10(6) PBMC, PBMC from SSc patients (n = 17) produced 8 times as much IL-2 as did PBMC from 16 normal...
Topics
- Adult
- Aged
- Arthritis, Rheumatoid
- Collagen
- Dose-Response Relationship, Drug
- Female
- Humans
- Interleukin-2
- Male
- Middle Aged
- Phenotype
- Phytohemagglutinins