Article
Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals.
FEBS letters - 16 Apr 2010
Heinen Christian, Garner Thomas P, Long Jed, Böttcher Claudia, Ralston Stuart H, Cavey James R, Searle Mark S, Layfield Robert, Dantuma Nico P
Abstract excerpt
We show that the ubiquitin-associated domain (UBA) of human p62/sequestosome-1 (SQSTM1) can delay degradation of proteasome substrates in yeast. Taking advantage of naturally occurring mutant UBA domains that are linked to Paget's disease of bone (PDB), we found that three of the four mutant UBA domains tested in this study were able to inhibit proteasomal degradation, albeit not to the same extent as the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.