Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p62 mutations, ubiquitin recognition and Paget's disease of bone.

Biochemical Society transactions - 1 Nov 2006

Layfield R, Cavey J R, Najat D, Long J, Sheppard P W, Ralston S H, Searle M S

Abstract excerpt

Functional analyses of PDB (Paget's disease of bone)-associated mutants of the p62 [also known as SQSTM1 (sequestosome 1)] signalling adaptor protein represent an interesting paradigm for understanding not only the disease mechanism in this skeletal disorder, but also the critical determinants of ubiquitin recognition by an ubiquitin-binding protein. The 11 separate PDB mutations identified to date all affect the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Mutation
Share to Osteitis Deformans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Protein Binding

Share to Proteins

Share to Sequestosome-1 Protein

Share to Ubiquitin

Source

Identifiers

PMID: 17052185
DOI: 10.1042/BST0340735

Genes

SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p62 mutations, ubiquitin recognition and Paget's disease of bone.PMID 17052185Read ↗

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.Semantic proximity Read ↗

SQSTM1 and Paget's disease of bone.Semantic proximity Read ↗

Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone.Semantic proximity Read ↗

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.Semantic proximity Read ↗

The adaptor protein p62/SQSTM1 in osteoclast signaling pathwaysSemantic proximity Read ↗

Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (<i>SQSTM1</i>) MutationsSemantic proximity Read ↗

Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone.Semantic proximity Read ↗

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences.Semantic proximity Read ↗

Disruption of ubiquitin-mediated processes in diseases of the brain and bone.Semantic proximity Read ↗

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.Semantic proximity Read ↗

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals.Semantic proximity Read ↗

Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.