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Article

SQSTM1 and Paget's disease of bone.

Calcified tissue international - 1 Nov 2004

Layfield R, Hocking L J

Abstract excerpt

Mutations in the Sequestosome 1 gene ( SQSTM1; also known as p62) have recently been identified as the cause of 5q35-linked Paget's disease of bone (PDB). All of the mutations identified to date affect the ubiquitin-associated (UBA) domain of SQSTM1, a region of the protein that binds noncovalently to ubiquitin. In this review we consider the possible functional significance of the SQSTM1-ubiquitin interaction,...

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Source

Identifiers

PMID: 15365659
DOI: 10.1007/s00223-004-0041-0

Genes

SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SQSTM1 and Paget's disease of bone.PMID 15365659Read ↗

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.Semantic proximity Read ↗

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Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone.Semantic proximity Read ↗

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences.Semantic proximity Read ↗

Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (<i>SQSTM1</i>) MutationsSemantic proximity Read ↗

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.Semantic proximity Read ↗

Paget's disease of bone: an update.Semantic proximity Read ↗

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals.Semantic proximity Read ↗

Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease.Semantic proximity Read ↗

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Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone.Semantic proximity Read ↗

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