Article
A functional promoter polymorphism in NFKB1 increases susceptibility to endometriosis.
DNA and cell biology - 1 May 2010
Zhou Bin, Rao Li, Peng Ying, Wang Yanyun, Qie Mingrong, Zhang Zhu, Song Yaping, Zhang Lin
Abstract excerpt
Numerous proinflammatory cytokines, such as TNFalpha and IL-6, which are nuclear factor kappaB (NF-kappaB) target genes, have been shown to promote proliferation in endometriotic cells, and several other genes involved in promoting growth are also NF-kappaB target genes. The aim of this study was to investigate whether the functional insertion/deletion polymorphism (-94 insertion/deletion ATTG) in the promoter of...
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