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Article

Seizure suppression by gain-of-function escargot mutations.

Genetics - 1 Mar 2005

Hekmat-Scafe Daria S, Dang Kim N, Tanouye Mark A

Abstract excerpt

Suppressor mutations provide potentially powerful tools for examining mechanisms underlying neurological disorders and identifying novel targets for pharmacological intervention. Here we describe mutations that suppress seizures in a Drosophila model of human epilepsy. A screen utilizing the Drosophila easily shocked (eas) "epilepsy" mutant identified dominant suppressors of seizure sensitivity. Among several...

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Identifiers

PMID: 15654097
DOI: 10.1534/genetics.104.036558
PMCID: PMC1449553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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