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Attenuation of Colistin Bactericidal Activity by High Inoculum of<i>Pseudomonas aeruginosa</i>Characterized by a New Mechanism-Based Population Pharmacodynamic Model

9 Mar 2010

Abstract excerpt

Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at several CFUo and developed a mechanism-based mathematical model accommodating a range of CFUo. In vitro time-kill...

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PMID: 20211900
DOI: 10.1128/aac.00881-09

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