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Deleterious amino acid polymorphisms in Arabidopsis thaliana and rice.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik - 1 Jun 2010

Günther Torsten, Schmid Karl J

Abstract excerpt

Plant genetic diversity has been mainly investigated with neutral markers, but large-scale DNA sequencing projects now enable the identification and analysis of different classes of genetic polymorphisms, such as non-synonymous single nucleotide polymorphisms (nsSNPs) in protein coding sequences. Using the SIFT and MAPP programs to predict whether nsSNPs are tolerated (i.e., effectively neutral) or deleterious...

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PMID: 20198468
DOI: 10.1007/s00122-010-1299-4

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