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The Role of Deleterious Substitutions in Crop Genomes.

Molecular biology and evolution - 1 Sept 2016

Kono Thomas J Y, Fu Fengli, Mohammadi Mohsen, Hoffman Paul J, Liu Chaochih, Stupar Robert M, Smith Kevin P, Tiffin Peter, Fay Justin C, Morrell Peter L

Abstract excerpt

Populations continually incur new mutations with fitness effects ranging from lethal to adaptive. While the distribution of fitness effects of new mutations is not directly observable, many mutations likely either have no effect on organismal fitness or are deleterious. Historically, it has been hypothesized that a population may carry many mildly deleterious variants as segregating variation, which reduces the...

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Source

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Identifiers

PMID: 27301592
DOI: 10.1093/molbev/msw102
PMCID: PMC4989107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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