Article
Comparative Genomics Approaches Accurately Predict Deleterious Variants in Plants.
G3 (Bethesda, Md.) - 3 Oct 2018
Kono Thomas J Y, Lei Li, Shih Ching-Hua, Hoffman Paul J, Morrell Peter L, Fay Justin C
Abstract excerpt
Recent advances in genome resequencing have led to increased interest in prediction of the functional consequences of genetic variants. Variants at phylogenetically conserved sites are of particular interest, because they are more likely than variants at phylogenetically variable sites to have deleterious effects on fitness and contribute to phenotypic variation. Numerous comparative genomic approaches have been...
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