Article
Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene in alcohol dependence: family and case control study.
Brain research - 23 Apr 2010
Samochowiec Agnieszka, Grzywacz Anna, Kaczmarek Leszek, Bienkowski Przemyslaw, Samochowiec Jerzy, Mierzejewski Paweł, Preuss Ulrich W, Grochans Elzbieta, Ciechanowicz Andrzej
Abstract excerpt
AIM: Matrix metalloproteinases (MMP) are extracellularly acting endopeptidases, whose substrates are extracellular matrix and adhesion proteins. In the gene polymorphism studies MMP-9 has been suggested to be involved in the pathogenesis of heart disease, cancer, bipolar disorder, and schizophrenia. In animal models MMP-9 has been shown to play a key role in a variety of neuronal plasticity phenomena, including...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.