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Sex-related differences in length and erosion dynamics of human telomeres favor females

14 Jul 2009

Abstract excerpt

Telomeres are repetitive DNA sequences at chromosomal ends contributing to genomic integrity. In somatic cells, telomeres are shortened during DNA reduplication. Thus, telomere erosion has been regarded as a biological clock. Applying the telomere/centromere (T/C)-FISH technique to human peripheral blood lymphocytes, we showed that pangenomically, telomere shortening is linear in centenarians and that this...

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Share to DNA Repair Mechanisms
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PMID: 20195387
DOI: 10.18632/aging.100068

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