An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects.

Abstract excerpt

Telomeres, repetitive DNA sequences found at the ends of linear chromosomes, play a role in regulating cellular proliferation, and shorten with increasing age in proliferating human tissues. The rate of age-related shortening of telomeres is highest early in life and decreases with age. Shortened telomeres are thought to limit the proliferation of cells and are associated with increased morbidity and mortality....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptation, Physiological
• Share to Aging