Article
Association of methylenetetrahydrofolate reductase (MTHFR 677C>T and 1298A>C) polymorphisms and haplotypes with silent brain infarction and homocysteine levels in a Korean population.
Yonsei medical journal - 1 Mar 2010
Han In Bo, Kim Ok Joon, Ahn Jung Yong, Oh Doyeun, Hong Sun Pyo, Huh Ryoong, Chung Sang Sup, Kim Nam Keun
Abstract excerpt
PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is the main regulatory enzyme for homocysteine metabolism. In the present study, we evaluated whether the MTHFR 677C>T and 1298A>C gene polymorphisms are associated with SBI and plasma homocysteine concentration in a Korean population. MATERIALS AND METHODS: We enrolled 264 patients with SBI and 234 healthy controls in South Korea. Fasting plasma total...
Topics
- Aged
- Asian People
- Brain Infarction
- Female
- Genotype
- Haplotypes
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged