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Article

Sex-linked dosage-sensitive modifiers as imprinting genes.

Development (Cambridge, England). Supplement - 1 Jan 1990

Sapienza C

Abstract excerpt

It is proposed that differential genome imprinting is the result of dosage-sensitive modifier genes located on the sex chromosomes. Parallels between variegating position-effects in Drosophila, the phenotype elicited by transgenes in the mouse and data from several pediatric tumors indicate that the net result of the activity of such modifier genes is often cellular mosaicism in the expression of affected...

Topics

Animals
Dosage Compensation, Genetic
Drosophila
Gene Expression Regulation
Humans
Huntington Disease
Models, Genetic
Phenotype
Regulatory Sequences, Nucleic Acid
Sex Chromosomes

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PMID: 2151032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2151032-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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