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Article

Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids.

Chemistry & biology - 23 Sept 2011

Schleifman Erica B, Bindra Ranjit, Leif Jean, del Campo Jacob, Rogers Faye A, Uchil Pradeep, Kutsch Olaf, Shultz Leonard D, Kumar Priti, Greiner Dale L, Glazer Peter M

Abstract excerpt

Peptide nucleic acids (PNAs) bind duplex DNA in a sequence-specific manner, creating triplex structures that can provoke DNA repair and produce genome modification. CCR5 encodes a chemokine receptor required for HIV-1 entry into human cells, and individuals carrying mutations in this gene are resistant to HIV-1 infection. Transfection of human cells with PNAs targeted to the CCR5 gene, plus donor DNAs designed to...

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Share to Antigens, CD34
Share to CCR5 Receptor Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21944757
DOI: 10.1016/j.chembiol.2011.07.010
PMCID: PMC3183429

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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