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Article

Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.

Blood - 29 Apr 2010

Fan Gaofeng, Simmons Matthew J, Ge Sheng, Dutta-Simmons Jui, Kucharczak Jérôme, Ron Yacov, Weissmann David, Chen Chiann-Chyi, Mukherjee Chandreyee, White Eileen, Gélinas Céline

Abstract excerpt

The antiapoptotic Bcl-2 family member Bfl-1 is up-regulated in many human tumors in which nuclear factor-kappaB (NF-kappaB) is implicated and contributes significantly to tumor cell survival and chemoresistance. We previously found that NF-kappaB induces transcription of bfl-1 and that the Bfl-1...

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Identifiers

PMID: 20185581
DOI: 10.1182/blood-2009-08-236760
PMCID: PMC2867266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20185581-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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