Article
Unsuspected poor metabolizer phenotypes of fluoxetine in bioavailability/bioequivalence studies from an indian population perspective. Retrospective pharmacokinetic data evaluation.
Arzneimittel-Forschung - 1 Jan 2010
Kandasamy Mani, Tripathy Krishnanand, Ravi Sandhya, Kamath Narendra, Pai Balakrishna, Srinivas Nuggehally R, Kristjansson Fjalar, Thangam Saral
Abstract excerpt
BACKGROUND: Fluoxetine, belonging to the class of selective serotonin uptake inhibitors, has been extensively used for the treatment of depression and other psychiatry related disorders. Fluoxetine (CAS 59333-67-4) is a substrate of polymorphic cytochrome P450 2D6 isozyme (CYP2D6) leading to the...
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