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Article

Study of the serotonin transporter (SLC6A4) and BDNF genes in French patients with non syndromic mental deficiency.

BMC medical genetics - 22 Feb 2010

Tabagh Refaat, Andres Christian R, Védrine Sylviane, Cherpi-Antar Catherine, Thepault Rose-Anne, Mignon Laurence, Dufour-Rainfray Diane, Moraine Claude, Vourc'h Patrick

Abstract excerpt

BACKGROUND: Mental deficiency has been linked to abnormalities in cortical neuronal network connectivity and plasticity. These mechanisms are in part under the control of two interacting signalling pathways, the serotonergic and the brain-derived neurotrophic (BDNF) pathways. The aim of the current paper is to determine whether particular alleles or genotypes of two crucial genes of these systems, the serotonin...

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Identifiers

PMID: 20175892
DOI: 10.1186/1471-2350-11-30
PMCID: PMC2837021

Genes

BDNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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