Article
Study of the serotonin transporter (SLC6A4) and BDNF genes in French patients with non syndromic mental deficiency.
BMC medical genetics - 22 Feb 2010
Tabagh Refaat, Andres Christian R, Védrine Sylviane, Cherpi-Antar Catherine, Thepault Rose-Anne, Mignon Laurence, Dufour-Rainfray Diane, Moraine Claude, Vourc'h Patrick
Abstract excerpt
BACKGROUND: Mental deficiency has been linked to abnormalities in cortical neuronal network connectivity and plasticity. These mechanisms are in part under the control of two interacting signalling pathways, the serotonergic and the brain-derived neurotrophic (BDNF) pathways. The aim of the curre...
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