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Article

R659X mutation in the MLH1 gene in hereditary non-polyposis colorectal cancer(HNPCC) in an Indian extended family.

The Indian journal of medical research - 1 Jan 2010

Rajender Singh, Pooja Singh, Kumar M V Kranthi, Karwasra Rajendra, Singh Lalji, Thangaraj Kumarasamy

Abstract excerpt

BACKGROUND & OBJECTIVE: Hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome), is a genetically heterogeneous disorder that is believed to account for 2-10 per cent of all the colorectal cancer cases. The disease follows autosomal dominant inheritance pattern with high penetrance (85%) and younger age of onset when compared to patients with sporadic tumours. HNPCC is associated with germ-line...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20167975

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

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