Article

Haplotype analysis detects MLH1 founder variant in Indian Lynch syndrome patient cohort

2024-12-10

Abstract excerpt

<title>Abstract</title> <p>Lynch syndrome (LS) is an autosomal dominant hereditary cancer predisposition syndrome whereby the lifetime risk of developing gastrointestinal and genitourinary cancers rises by to over 50%. It is caused by heterozygous variants in the DNA mismatch repair genes- <italic>MLH1, MSH2, MSH6 </italic>and <italic>PMS2</italic>, with the majority detected in <italic>MLH1 </italic>and <italic>...

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Literature Corpus work: e1685c05-6c6d-5542-ad35-7a00874e2868
DOI: 10.21203/rs.3.rs-5247105/v1

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