Article
Possible influence of variant of the P-glycoprotein gene (MDR1/ABCB1) on clinical response to guanfacine in children with pervasive developmental disorders and hyperactivity.
Journal of child and adolescent psychopharmacology - 1 Feb 2010
McCracken James T, Aman Michael G, McDougle Christopher J, Tierney Elaine, Shiraga Sharon, Whelan Fiona, Arnold L Eugene, Posey David, Ritz Louise, Vitiello Benedetto, Scahill Lawrence
Abstract excerpt
OBJECTIVE: Guanfacine has been shown to reduce hyperactive behaviors in children with attention-deficit/hyperactivity disorder (ADHD) and possibly in children with pervasive developmental disorder (PDD) and hyperactivity. The aim of this exploratory study was to examine whether gene variants enco...
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