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Article

ABCB1 c.2677G>T variation is associated with adverse reactions of OROS-methylphenidate in children and adolescents with ADHD.

Journal of clinical psychopharmacology - 1 Aug 2013

Kim So Won, Lee Ji Hyun, Lee Sung Hee, Hong Hyun Ju, Lee Min Goo, Yook Ki-Hwan

Abstract excerpt

OBJECTIVES: Osmotic-release oral system (OROS)-methylphenidate (MPH) is a safe and well-tolerated drug. Some patients cannot continue this regimen with adverse drug reactions (ADRs). As drug efflux transporters of the central nervous system, ABCB1 plays an important role in the clearance of psychotropic drugs and their metabolites from brain tissues. We hypothesized that genetic variations in the ABCB1 gene may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23771192
DOI: 10.1097/JCP.0b013e3182905a8d

Genes

ABCB1

Variants

Provenance

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