Article
Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2008
Dong Hongxin, Yuede Carla M, Coughlan Carolyn, Lewis Brian, Csernansky John G
Abstract excerpt
Memantine, an uncompetitive NMDA receptor antagonist used for the treatment of Alzheimer's disease (AD), has been hypothesized to have neuroprotective properties. However, the similarity of its mechanism of action to other NMDA receptor antagonists has led to concerns that it may also have neurotoxic effects. To assess both the neuroprotective and neurotoxic potential of memantine in a mouse model of AD (Tg2576...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.