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Article

Bone response to fluoride exposure is influenced by genetics.

PloS one - 1 Jan 2014

Kobayashi Cláudia A N, Leite Aline L, Peres-Buzalaf Camila, Carvalho Juliane G, Whitford Gary M, Everett Eric T, Siqueira Walter L, Buzalaf Marília A R

Abstract excerpt

Genetic factors influence the effects of fluoride (F) on amelogenesis and bone homeostasis but the underlying molecular mechanisms remain undefined. A label-free proteomics approach was employed to identify and evaluate changes in bone protein expression in two mouse strains having different susceptibilities to develop dental fluorosis and to alter bone quality. In vivo bone formation and histomorphometry after F...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25501567
DOI: 10.1371/journal.pone.0114343
PMCID: PMC4263599

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