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Article

Yeast Tdp1 regulates the fidelity of nonhomologous end joining.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2010

Bahmed Karim, Nitiss Karin C, Nitiss John L

Abstract excerpt

Tyrosyl-DNA-phosphodiesterase 1 (Tdp1) can disjoin peptides covalently bound to DNA. We assessed the role of Tdp1 in nonhomologous end joining (NHEJ) and found that linear DNA molecules with 5' extensions showed a high frequency of misrepair in Deltatdp1 cells. The joining errors in Deltatdp1 cel...

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Identifiers

PMID: 20160111
DOI: 10.1073/pnas.0909917107
PMCID: PMC2840102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20160111-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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