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Article

Topology of the membrane-bound form of complement protein C9 probed by glycosylation mapping, anti-peptide antibody binding, and disulfide modification.

Molecular immunology - 1 Apr 2010

Rossi Véronique, Wang Yunxia, Esser Alfred F

Abstract excerpt

The two N-linked oligosaccharides in native human C9 were deleted by site-specific mutagenesis. This aglycosyl-C9 did not differ from its native form in hemolytic and bactericidal activity. A new N-glycosylation site (K311N/E313T) was introduced into the turn of a helix-turn-helix [HTH] fold that had been postulated to form a transmembrane hairpin in membrane-bound C9. This glycosylated form of human C9 was as...

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Identifiers

PMID: 20153530
DOI: 10.1016/j.molimm.2010.01.013
PMCID: PMC2849895

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Source receipt: pubmed, retrieved 7 Sept 2026.

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