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Article

A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.

Clinical pharmacology and therapeutics - 1 Jun 2010

Dumond J B, Vourvahis M, Rezk N L, Patterson K B, Tien H-C, White N, Jennings S H, Choi S O, Li J, Wagner M J, La-Beck N M, Drulak M, Sabo J P, Castles M A, Macgregor T R, Kashuba A D M

Abstract excerpt

The effects of tipranavir/ritonavir (TPV/r) on hepatic and intestinal P-glycoprotein (P-gp) and cytochrome P450 (CYP) enzyme activity were evaluated in 23 volunteers. The subjects received oral (p.o.) caffeine, warfarin + vitamin K, omeprazole, dextromethorphan, and midazolam and digoxin (p.o. an...

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Identifiers

PMID: 20147896
DOI: 10.1038/clpt.2009.253
PMCID: PMC2882206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20147896-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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