Article
Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir.
Clinical pharmacology and therapeutics - 1 Aug 2006
Mikus Gerd, Schöwel Verena, Drzewinska Magdalena, Rengelshausen Jens, Ding Reinhard, Riedel Klaus-Dieter, Burhenne Jürgen, Weiss Johanna, Thomsen Torben, Haefeli Walter E
Abstract excerpt
OBJECTIVES: Cytochrome P450 (CYP) 2C19 and CYP3A4 are the major enzymes responsible for voriconazole elimination. Because the activity of CYP2C19 is under genetic control, the extent of inhibition with a CYP3A4 inhibitor was expected to be modulated by the CYP2C19 metabolizer status. This study thus assessed the effect of the potent CYP3A4 inhibitor ritonavir after short-term administration on voriconazole...
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