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Article

ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.

Science signaling - 9 Feb 2010

Kuo Hsu-Ping, Lee Dung-Fang, Chen Chun-Te, Liu Mo, Chou Chao-Kai, Lee Hong-Jen, Du Yi, Xie Xiaoming, Wei Yongkun, Xia Weiya, Weihua Zhang, Yang Jer-Yen, Yen Chia-Jui, Huang Tzu-Hsuan, Tan Minjia, Xing Gang, Zhao Yingming, Lin Chien-Hsing, Tsai Shih-Feng, Fidler Isaiah J, Hung Mien-Chie

Abstract excerpt

Mammalian target of rapamycin (mTOR) regulates various cellular functions, including tumorigenesis, and is inhibited by the tuberous sclerosis 1 (TSC1)-TSC2 complex. Here, we demonstrate that arrest-defective protein 1 (ARD1) physically interacts with, acetylates, and stabilizes TSC2, thereby repressing mTOR activity. The inhibition of mTOR by ARD1 inhibits cell proliferation and increases autophagy, thereby...

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Source

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Identifiers

PMID: 20145209
DOI: 10.1126/scisignal.2000590
PMCID: PMC2874891

Genes

TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.PMID 20145209Read ↗

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Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cancer.Semantic proximity Read ↗

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Growth Control Under Stress: mTOR Regulation through the REDD1-TSC PathwaySemantic proximity Read ↗

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The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cellsSemantic proximity Read ↗

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.Semantic proximity Read ↗

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2Semantic proximity Read ↗

AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous SchedulesSemantic proximity Read ↗

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.Semantic proximity Read ↗

Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.Semantic proximity Read ↗

Arrest Defective 1 Autoacetylation Is a Critical Step in Its Ability to Stimulate Cancer Cell ProliferationSemantic proximity Read ↗

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