Molecular characterization of single memory B cells.

doi:10.1038/350502a0

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Article

Molecular characterization of single memory B cells.

Nature - 11 Apr 1991

McHeyzer-Williams M G, Nossal G J, Lalor P A

Abstract excerpt

Primary antigenic exposure results in an initial antibody response and the T cell-dependent induction of B-cell memory. Memory B-cell differentiation is characterized by somatic hypermutation in antibody variable region genes (V) and selection of B cells expressing high-affinity variants of this antigen receptor. Despite our current understanding of B-cell memory, the origin of memory B cells and the regulation...

Topics

Amino Acid Sequence
Animals
Antibody Formation
Antigens
B-Lymphocytes
Base Sequence
Cell Differentiation
Cells, Cultured
Flow Cytometry
Immunoglobulin G
Immunoglobulin Variable Region
Immunologic Memory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Receptors, Antigen, B-Cell

Source

Open in PubMed

Identifiers

PMID: 2014051
DOI: 10.1038/350502a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2014051-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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