Article
Molecular characterization of single memory B cells.
Nature - 11 Apr 1991
McHeyzer-Williams M G, Nossal G J, Lalor P A
Abstract excerpt
Primary antigenic exposure results in an initial antibody response and the T cell-dependent induction of B-cell memory. Memory B-cell differentiation is characterized by somatic hypermutation in antibody variable region genes (V) and selection of B cells expressing high-affinity variants of this antigen receptor. Despite our current understanding of B-cell memory, the origin of memory B cells and the regulation...
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