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Article

Ume6 is required for the MATa/MATalpha cellular identity and transcriptional silencing in Kluyveromyces lactis.

Genetics - 1 Apr 2010

Barsoum E, Sjöstrand J O O, Aström S U

Abstract excerpt

To explore the similarities and differences of regulatory circuits among budding yeasts, we characterized the role of the unscheduled meiotic gene expression 6 (UME6) gene in Kluyveromyces lactis. We found that Ume6 was required for transcriptional silencing of the cryptic mating-type loci HMLalpha and HMRa. Chromatin immunoprecipitation (ChIP) suggested that Ume6 acted directly by binding the cis-regulatory...

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Identifiers

PMID: 20139343
DOI: 10.1534/genetics.110.114678
PMCID: PMC2865933

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