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Article

Public TCR Use by Herpes Simplex Virus-2–Specific Human CD8 CTLs

5 Feb 2010

Abstract excerpt

Recombination of germline TCR alpha and beta genes generates polypeptide receptors for MHC peptide. Ag exposure during long-term herpes simplex infections may shape the T cell repertoire over time. We investigated the CD8 T cell response to HSV-2 in chronically infected individuals by sequencing the hypervariable regions encoding TCR alpha and beta polypeptides from T cell clones recognizing virion protein 22 aa...

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PMID: 20139278
DOI: 10.4049/jimmunol.0903622

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