Article
Lack of association between PCK1 polymorphisms and obesity, physical activity, and fitness in European Youth Heart Study (EYHS).
Obesity (Silver Spring, Md.) - 1 Oct 2010
Vimaleswaran Karani S, Franks Paul W, Brage Soren, Grontved Anders, Wareham Nicholas J, Ekelund Ulf, Loos Ruth J F
Abstract excerpt
Phosphoenolpyruvate carboxykinase-1 (PCK1) is the rate-limiting enzyme in the hepatic gluconeogenic pathway. Studies have shown that overexpression of Pck1 in mice results in obesity-related traits and higher levels of physical activity (PA). Therefore, our aims were to investigate whether common genetic variation in the PCK1 gene influences obesity-related traits, PA, and fitness, and to examine whether PA and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.