Article
PPARGC1A sequence variation and cardiovascular risk-factor levels: a study of the main genetic effects and gene x environment interactions in children from the European Youth Heart Study.
Diabetologia - 1 Apr 2009
Brito E C, Vimaleswaran K S, Brage S, Andersen L B, Sardinha L B, Wareham N J, Ekelund U, Loos R J F, Franks P W
Abstract excerpt
AIMS/HYPOTHESIS: The PPARGC1A gene coactivates multiple nuclear transcription factors involved in cellular energy metabolism and vascular stasis. In the present study, we genotyped 35 tagging polymorphisms to capture all common PPARGC1A nucleotide sequence variations and tested for association with metabolic and cardiovascular traits in 2,101 Danish and Estonian boys and girls from the European Youth Heart Study,...
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