Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A truncated lipoglycan from mycobacteria with altered immunological properties.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010

Birch Helen L, Alderwick Luke J, Appelmelk Ben J, Maaskant Janneke, Bhatt Apoorva, Singh Albel, Nigou Jerome, Eggeling Lothar, Geurtsen Jeroen, Besra Gurdyal S

Abstract excerpt

Maintenance of cell-wall integrity in Mycobacterium tuberculosis is essential and is the target of several antitubercular drugs. For example, ethambutol targets arabinogalactan and lipoarabinomannan (LAM) biosynthesis through the inhibition of several arabinofuranosyltransferases. Apart from thei...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ethambutol
Share to Antigens, Bacterial
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-8

Share to Magnetic Resonance Spectroscopy

Share to Mycobacterium smegmatis

Share to Pentosyltransferases

Share to Toll-Like Receptor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 20133807
DOI: 10.1073/pnas.0915082107
PMCID: PMC2823879

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20133807-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A truncated lipoglycan from mycobacteria with altered immunological properties.PMID 20133807Read ↗

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan.Semantic proximity Read ↗

Cell Surface Biosynthesis and Remodeling Pathways in Mycobacteria Reveal New Drug TargetsSemantic proximity Read ↗

Truncated Structural Variants of Lipoarabinomannan in Mycobacterium leprae and an Ethambutol-resistant Strain of Mycobacterium tuberculosisSemantic proximity Read ↗

Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan.Semantic proximity Read ↗

Characterization of a distinct arabinofuranosyltransferase in Mycobacterium smegmatis.Semantic proximity Read ↗

Revisiting Anti-tuberculosis Therapeutic Strategies That Target the Peptidoglycan Structure and SynthesisSemantic proximity Read ↗

Mycobacterial cell wall biosynthesis: a multifaceted antibiotic targetSemantic proximity Read ↗

Variation in Mannose-capped Terminal Arabinan Motifs of Lipoarabinomannans from Clinical Isolates of Mycobacterium tuberculosis and Mycobacterium avium ComplexSemantic proximity Read ↗

Roles of conserved proline and glycosyltransferase motifs of EmbC in biosynthesis of lipoarabinomannan.Semantic proximity Read ↗

Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase.Semantic proximity Read ↗

The critical role of embC in Mycobacterium tuberculosis.Semantic proximity Read ↗

Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.