Article
Different mechanisms inferred from sequences of human mitochondrial DNA deletions in ocular myopathies.
Nucleic acids research - 11 Feb 1991
Degoul F, Nelson I, Amselem S, Romero N, Obermaier-Kusser B, Ponsot G, Marsac C, Lestienne P
Abstract excerpt
We have sequenced the deletion borders of the muscle mitochondrial DNA from 24 patients with heteroplasmic deletions. The length of these deletions varies from 2.310 bp to 8.476 bp and spans from position 5.786 to 15.925 of the human mitochondrial genome preserving the heavy chain and light chain origins of replication. 12 cases are common deletions identical to the mutation already described by other workers and...
Topics
- Base Sequence
- DNA, Mitochondrial
- Eye Diseases
- Humans
- Mitochondria, Muscle
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Recombination, Genetic