Article
Frameshift deletion mechanisms in Egyptian Duchenne and Becker muscular dystrophy families.
Molecules and cells - 31 Oct 2004
Elhawary Nasser A, Nasser A Elhawary, Shawky Rabah Mohamad, Hashem Nemat
Abstract excerpt
Partial gene deletion is the major type of mutation leading to Duchenne muscular dystrophy (DMD) and its mild allelic form, Becker muscular dystrophy (BMD). Amplification of the genomic DNAs of 152 unrelated dystrophin patients using multiple primers detected 78 (51.3%) probands with deletion mutations. We predicted the translational reading frame for all the deletions in Egyptian dystrophin males. The frameshift...
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