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Circulating proteins linked to apoptosis processes and fast development of end-stage kidney disease in diabetes

22 Oct 2024

Abstract excerpt

Many circulating proteins are associated with risk of ESKD, but their source and the biological pathways/disease processes they represent are unclear. Using OLINK proteomics platform, concentrations of 455 proteins were measured in plasma specimens obtained at baseline from 399 individuals with diabetes. Elevated concentrations of 46 circulating proteins were associated (P < 1 × 10-5) with development of ESKD (n...

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PMID: 39435665
DOI: 10.1172/jci.insight.178373

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